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« Back to home page| Title | New synthetic approaches enabled by electrochemistry and a nanoporous gold catalyst: for the N-dealkylation of tropanes, opiates and other drug molecules |
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| Identifier | https://research.rug.nl/en/publications/65088247-f954-484d-a412-9a36a394ae81 |
| Identifier | urn:nbn:nl:ui:11-65088247-f954-484d-a412-9a36a394ae81 |
| Identifier | 65088247-f954-484d-a412-9a36a394ae81 |
| Identifier | 11370/65088247-f954-484d-a412-9a36a394ae81 |
| Identifier | 10.33612/diss.232788033 |
| Identifier | urn:nbn:nl:ui:11-65088247-f954-484d-a412-9a36a394ae81 |
| Identifier | https://research.rug.nl/en/publications/65088247-f954-484d-a412-9a36a394ae81 |
| Publisher | University of Groningen |
| Abstract | Carbon-nitrogen bond cleavage in the form of N-dealkylation is an important chemical transformation which provides routes for the synthesis of a wide range of pharmaceuticals, agrochemicals, bulk and fine chemicals. N-dealkylation of amines is also an important in vivo metabolic pathway in the metabolism of xenobiotics and drugs. Identification and synthesis of drug metabolites such as N-dealkylated metabolites are necessary throughout all phases of drug development studies. In this thesis, three novel synthetic routes are explored for the N-dealkylation of various secondary and tertiary amines to synthesize added-value pharmaceutical intermediates and drug metabolites based on electrochemistry and a nanoporous gold catalyst. |
| Date | 2022 |
| Type | info:eu-repo/semantics/doctoralthesis |
| Language | en |
| Relation |
https://pure.rug.nl/ws/files/232788035/Title_and_contents.pdf https://pure.rug.nl/ws/files/232788037/Chapter_1.pdf https://pure.rug.nl/ws/files/232788039/Chapter_2.pdf https://pure.rug.nl/ws/files/232788041/Chapter_3.pdf https://pure.rug.nl/ws/files/232788045/Chapter_5.pdf https://pure.rug.nl/ws/files/232788047/Summary.pdf https://pure.rug.nl/ws/files/232788049/Samenvatting.pdf https://pure.rug.nl/ws/files/232788051/Appendix.pdf https://pure.rug.nl/ws/files/232788055/Propositions.pdf |
| Format | application/pdf |
| Format | application/pdf |
| Format | application/pdf |
| Format | application/pdf |
| Format | application/pdf |
| Format | application/pdf |
| Format | application/pdf |
| Format | application/pdf |
| Format | application/pdf |
| Author | Alipour Najmi Iranag, Ali |
| Contributors | Bischoff, Rainer; Permentier, Hjalmar; Analytical Biochemistry |
| Rights | info:eu-repo/semantics/openAccess |